Oloker Therapeutics is a biotechnology start-up committed to discovery, development and commercialization of cellular therapies for the treatment of cardiovascular disease. Our mission is to bring to light new innovative cellular therapies for unmet clinical needs that can improve patients’ prognosis and quality of life through extensive scientific research and in-depth knowledge of cardiovascular diseases.
Translating science from the Lab to the Clinic
The invention, christened CPCPlus, is a product-by-process intended to comply, according to EMA guidelines and EU legislation, with the ATMP classification. CPCPlus therapy is conceived as a novel cost-effective cardiac ATMP directly delivered through specific catheters into the ischemic heart. The product exerts a potent angiogenic effect into the ischemic myocardium. From a clinical standpoint, the technology is aimed to cover the lack of therapy for patients dealing with refractory angina, a no-option heart condition due to inadequate oxygen supply to the cardiac muscle.
The key aspects of CPCPlus are summarized below:
The Oloker Therapeutics core technology, christened CPCPlus, is proprietary product-by-process platform including: 1) a method for cardiac-derived cell selection and expansion and 2) a newly discovered subpopulation of stromal-derived cardiac cells. We have developed a proprietary fully GMP-compliant manufacturing process that enables a high-efficient and cost-effective scalable expansion of our human cardiac progenitor cells (hCmPC), while maintaining their ability to produce key molecules associated with neovascularization, immunomodulation and tissue repair. Our cell product can be exploited both in autologous and “off-the-shelf” allogenic setting. Our technology enables to release a cell product with consistent, well-defined therapeutic properties, batch release criteria and potency assays, all with economy of scale criteria.
Piazza Giuseppe Massari 19 – 70122 Bari (Italy) – c/o Siryo S.p.A.
Codice Destinatario: M5UXCR1
c/o Centro Cardiologico Monzino,
Via Carlo Parea 4,
20138 Milano (Italy)